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There are several methods to do a colon cleanse, including enemas, herbal supplements, and colon hydrotherapy. Enemas involve the use of a liquid solution that is introduced into the rectum to remove waste. Herbal supplements like psyllium husk and bentonite clay can assist in removing toxins and waste from the colon. Colon hydrotherapy is a more advanced method that involves the use of specialized equipment to flush out the colon using warm water.